Blood-brain barrier development: Systems modeling and predictive toxicology
نویسندگان
چکیده
منابع مشابه
Predictive Systems Toxicology
In this review we address to what extent computational techniques can augment our ability to predict toxicity. The first section provides a brief history of empirical observations on toxicity dating back to the dawn of Sumerian civilization. Interestingly, the concept of dose emerged very early on, leading up to the modern emphasis on kinetic properties, which in turn encodes the insight that t...
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are that in vitro models do not fully recapitulate the in vivo BBB and difficulties in obtaining the appropriate human tissue necessary for in vitro modeling. The paper in this issue by Lippmann et al. (2011) from the group of Eric Shusta, is an important step towards resolving both these issues. The BBB is formed by the cerebral endothelial cells and their linking tight junctions. However, BBB...
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ژورنال
عنوان ژورنال: Birth Defects Research
سال: 2017
ISSN: 2472-1727
DOI: 10.1002/bdr2.1180